Appendix I

THE UNIVERSITY OF CALIFORNIA COLLEGE OF VETERINARY MEDICINE November 15, 1999

Department of Pathology, Microbiology, Immunology

Haring Hall

University of California

Davis, CA 95616

phone: 530- 754-7567   FAX: 530-752- 3349

Dear Zoological Veterinarian,

Because of increasing concerns that contraceptives may be causing pathological effects in the reproductive organs of many species, the AAZPA Contraceptive Committee Pathology Survey will be extended to INCLUDE THE REPRODUCTIVE TRACTS OF ALL FEMALE CARNIVORES AND PRIMATES. We will also be CONTINUING THE SURVEY OF FELID REPRODUCTIVE TRACTS. I would be very grateful if you would be willing to participate in the continuation of this study in felids and initiation of this survey in carnivores and primates.

For this study, I need intact, fixed reproductive tracts (uterus and ovaries) from ANY FEMALE CARNIVORE OR PRIMATE, REGARDLESS OF THE CONTRACEPTIVE HISTORY. Reproductive tracts either from necropsies or ovariohysterectomies would be appropriate. The tracts can be fixed in buffered formalin by emersion of the entire tract for 72 hours if a small incision is made into the lumen of the uterus at each horn (ratio of tissue to formalin = 1:10). Fixed tracts then can be wrapped in formalin-soaked paper towels, enclosed in a leak-proof plastic bag and shipped by ground US mail (Federal Express is not necessary). I have enclosed several mailing labels to make this more convenient. For this study, it is essential that you also provide the INFORMATION REQUESTED ON THE ENCLOSED FORM. This provides valuable data on the duration and dose of contraceptive treatment and the effects of age and parity on the lesions.

When the data is collated, I will send a brief report on the reproductive tract to you and will be certain to acknowledge your contribution in any publication resulting from this study.

I thank you in advance for contributing to this study. I am hoping that the results will provide information that will allow us to use these contraceptives in regimes that will minimize disease problems.

Sincerely yours,

Linda Munson, D.V.M., Ph.D.

THE UNIVERSITY OF CALIFORNIA COLLEGE OF VETERINARY MEDICINE  November 15, 1999

AZA CONTRACEPTIVE PATHOLOGY SURVEY

 SUBI@MTTING VETERINARIAN:

ZOO:

ADDRESS:

ANIMAL ID:          ISIS:             ZOO ID:         SB#:                  NAME:

SPECIES:                                                         DATE OF BIRTH:

DATE OF DEATH OR SPAY:                                  WEIGHT:

BREEDING HISTORY:

HAS THIS ANIMAL BEEN CYCLING?

HAS THIS ANIMAL BEEN BRED?

NUMBER AND DATES OF PREGNANCIES:

HAS THIS ANIMAL SHOWN ESTRUS WHEN IMPLANTED?

IMPLANT#        IMPLANT WEIGHT         ANIMAL WEIGHT         DATE INSERTED         DATE REMOVED

_____________ __________ ___________ ___________ ____________

_____________ __________ ___________ ___________ ____________

_____________ __________ ___________ ___________ ____________

_____________ __________ ___________ ___________ ____________

CONTRACEPTIVE TYPE:

DOSE OF CONTRACEPTIVE:

DATES OF TREATMENT: